- Recently Published Papers -

Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice

Abigail O’niel, Alexandra Pederson, Elizabeth Saltonstall, Kayla Nguyen, Monzerrat Pantoja, Mitali Chaudhari, Phoebe Sandholm, Eric Yoon, Henry F. Harrison, Sydney Boutros, Alec J. Hirsch, & Jacob Raber 

Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats

Jacob Raber, Sarah Holden, Kat Kessler, Breanna Glaeser, Chloe McQuesten, Mitali Chaudhari, Fiona Stenzel, Marek Lenarczyk, Scott Willem Leonard, Jeffrey Morre, Jaewoo Choi, Amy Kronenberg, Alexander Borg, Andy Kwok, Jan Frederik Stevens, Christopher Olsen, Jeffrey S. Willey, Gerd Bobe, Jessica Minnier, & John E. Baker

-Raber Lab News-

Updated opportunities for graduate students and post-doctoral fellows. “Neuroscience of Aging, Neurodegeneration and Alzheimer's Disease” NIAA T32 (MPIs Raber, Urbanski) renewed (2023-2028).

Based on what we learn in the rodent models and in nonhuman primate models, we develop tests and treatment strategies to improve brain function in humans suffering from these conditions. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches. For example, as part of collaborative efforts, we perform unbiased omics approaches to determine whether the behavioral and cognitive alterations are associated with alterations in specific pathways and whether behavioral and cognitive measures are related to specific biomarkers. As part of translation research, we developed and use humanized versions of the mouse object recognition and spatial navigation tests. These tests might be valuable in identifying biomarkers of cognitive function, of response to interventions, and susceptibility to cognitive impairments. 

Established at OHSU in 2001, the Raber Lab focuses on effects of genetic factors, such as apoE, and environmental factors, including irradiation, immunotherapy, chemotherapy, a Western diet, environmental toxins, and other stressors, on brain structure and function in experimental rodent models of human neurological diseases.