- Recently Published Papers -

Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice

Ariel Chaklai, Elizabeth M. Rhea, Abigail O’Niel, Alice Babin, Riley Weaver, Sarah Pemberton, William A. Banks & Jacob Raber 

-Raber Lab News-

Congratulations to Sydney Boutros for her nomination for the Outstanding Journal Article Award by the Graduate Studies Awards Committee at Oregon Health & Science University. Read her article here.

Updated opportunities for graduate students and post-doctoral fellows. “Neuroscience of Aging, Neurodegeneration and Alzheimer's Disease” NIAA T32 (MPIs Raber, Urbanski) renewed (2023-2028).

Based on what we learn in the rodent models and in nonhuman primate models, we develop tests and treatment strategies to improve brain function in humans suffering from these conditions. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches. For example, as part of collaborative efforts, we perform unbiased omics approaches to determine whether the behavioral and cognitive alterations are associated with alterations in specific pathways and whether behavioral and cognitive measures are related to specific biomarkers. As part of translation research, we developed and use humanized versions of the mouse object recognition and spatial navigation tests. These tests might be valuable in identifying biomarkers of cognitive function, of response to interventions, and susceptibility to cognitive impairments. 

Established at OHSU in 2001, the Raber Lab focuses on effects of genetic factors, such as apoE, and environmental factors, including irradiation, immunotherapy, chemotherapy, a Western diet, environmental toxins, and other stressors, on brain structure and function in experimental rodent models of human neurological diseases.